Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 12/20 | 0.56 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.56 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.56 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.56 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.56 |
| ▸ | LPAR3 | Q9UBY5 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636106 | 0.92 | LPAR1 (0.47) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2636319 | 0.91 | LPAR1 (0.45) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2636412 | 0.91 | LPAR1 (0.47) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2761251 | 0.91 | LPAR1 (0.48) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2635764 | 0.90 | LPAR1 (0.57) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2636366 | 0.90 | LPAR1 (0.60) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2636093 | 0.90 | LPAR1 (0.60) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2761308 | 0.89 | LPAR1 (0.43) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6695 | 0.89 | LPAR1 (0.67) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL2761503 | 0.88 | LPAR1 (0.42) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438048-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141768-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141761-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |