⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15345993 | 0.93 | SPPL2A (0.54) | — | |
| SCHEMBL15345991 | 0.93 | SPPL2A (0.54) | — | |
| SCHEMBL12783335 | 0.93 | — | — | |
| SCHEMBL13174238 | 0.93 | — | — | |
| SCHEMBL1804867 | 0.90 | SPPL2A (0.60) | — | |
| SCHEMBL1804868 | 0.90 | SPPL2A (0.60) | — | |
| SCHEMBL1804866 | 0.90 | SPPL2A (0.60) | — | |
| SCHEMBL6099960 | 0.90 | SPPL2A (0.60) | — | |
| SCHEMBL2903476 | 0.90 | SPPL2A (0.57) | — | |
| SCHEMBL2903479 | 0.90 | SPPL2A (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570416-B1 | Antiviral bisfuran derivative as hiv protease inhibitor and intermediates thereof | GILEAD SCIENCES INC (US) | 2016-03-16 | — | — | EP | disclosed |
| US-20130172295-A1 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-8431745-B2 | Process for preparation of HIV protease inhibitors | GILEAD SCIENCES, INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120258935-A1 | PROCESS FOR PREPARATION OF HIV PROTEASE INHBITORS | GILEAD SCIENCES, INC. (US) | 2012-10-11 | — | — | US | disclosed |
| US-20110065631-A1 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS | GILEAD SCIENCES, INC (US) | 2011-03-17 | — | — | US | disclosed |