Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.43 |
| ▸ | NRAS | P01111 | 5/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29370165 | 0.85 | FLT3 (0.53) | FLT3NRASIRAK4IRAK1LCK | |
| SCHEMBL24231464 | 0.85 | FLT3 (0.53) | FLT3NRASIRAK4IRAK1LCK | |
| SCHEMBL29372529 | 0.84 | FLT3 (0.45) | FLT3NRASIRAK4IRAK1LCK | |
| SCHEMBL24231659 | 0.84 | FLT3 (0.45) | FLT3NRASIRAK4IRAK1LCK | |
| SCHEMBL26359077 | 0.83 | FLT3 (0.49) | FLT3NRASEIF2AK4GABRA1GABRG2 | |
| SCHEMBL29372532 | 0.79 | FLT3 (0.41) | FLT3NRASEIF2AK4GABRA1GABRG2 | |
| SCHEMBL24231728 | 0.79 | FLT3 (0.41) | FLT3NRASEIF2AK4GABRA1GABRG2 | |
| SCHEMBL26359283 | 0.79 | FLT3 (0.52) | FLT3NRASIRAK4IRAK1LCK | |
| SCHEMBL26357801 | 0.78 | NRAS (0.45) | FLT3NRASIRAK4IRAK1LCK | |
| SCHEMBL24231470 | 0.78 | FLT3 (0.51) | FLT3NRASEIF2AK4GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303563-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303563-A1 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | FLT3, IRAK2, IRAK3 | FLT3 1/4885NRAS 259/4885EIF2AK4 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.