Naphthalene

Naphthalene

SCHEMBL263645

CC(=O)O.c1ccc2ccccc2c1

nearest known ligand 0.53

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Naphthalene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.53
ALOX12 P18054 1/20 0.53
CES2 O00748 4/20 0.50
CES1 P23141 4/20 0.50
NAPRT Q6XQN6 2/20 0.48
HSD17B10 Q99714 2/20 0.48
FFAR3 O14843 1/20 0.47
LCK P06239 1/20 0.47
FYN P06241 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
MAPT P10636 1/20 0.46
ALDH1A1 P00352 5/20 0.45
TSHR P16473 2/20 0.45
DAO P14920 1/20 0.45
ALOX15 P16050 1/20 0.45
NOTUM Q6P988 1/20 0.44
GLA P06280 2/20 0.44
KDM4E B2RXH2 2/20 0.44
HPGD P15428 2/20 0.44
NR4A1 P22736 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthalene SCHEMBL28769152 1.00 CYP2A6 (0.53) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL27548576 1.00 CYP2A6 (0.53) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL28104781 1.00 CYP2A6 (0.53) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL3759523 1.00 CYP2A6 (0.53) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL14715874 0.97 CYP2A6 (0.50) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL15903556 0.97 CYP2A6 (0.50) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL14715817 0.97 CYP2A6 (0.50) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL15903553 0.97 CYP2A6 (0.50) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL14715829 0.97 CYP2A6 (0.50) CYP2A6ALOX12CES2CES1NAPRT
Naphthalene SCHEMBL28117255 0.97 CYP2A6 (0.50) CYP2A6ALOX12CES2CES1NAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6361 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122074491-A Use of Gu Weijun element and naphthalene acetic acid or their salts for promoting cucumber growth and method thereof 2026-05-26 CN claimed
CN-117732450-B Chitosan-MOFs composite material and preparation method and application thereof JILIN UNIVERSITY (CN) 2026-05-26 CN claimed
EP-4743580-A1 EFFICIENT TRANSGENE-FREE GENOME EDITING IN PLANTS IN THE T0 GENERATION BASED ON A CO-EDITING STRATEGY University of Florida Research Foundation, Incorporated (US) 2026-05-20 EP claimed
CN-118160522-B Ginkgo large-scale cutting cultivation method and cutting method thereof 扬州大学 2026-05-19 CN claimed
CN-122030158-A Plant cold-proof stress-resistant freezing-proof method for enhancing plant respiration conduction efficiency 刘紫怡 2026-05-15 CN claimed
CN-122030263-A Efficient and stable proliferation-inducing black rose callus culture medium and culture method 杭州拾光欣雅生物技术有限公司 2026-05-15 CN claimed
CN-122012372-A Camellia nitidissima suspension cell culture method 大连普瑞康生物技术有限公司 2026-05-12 CN claimed
CN-122010615-A Nutrient solution for cultivation of herba cynarae scolymus and cultivation method 岭南现代农业科学与技术广东省实验室河源分中心 2026-05-12 CN claimed
US-12618029-B2 Method for producing agave cultures for tequila PHYTOTEQ, INC. (US) 2026-05-05 US claimed
EP-3485726-B1 CULTURING METHOD FOR CULTURED LEGUMINOUS ROOTS HAVING INCREASED COUMESTROL CONTENT AMOREPACIFIC CORP (KR) 2026-03-25 EP claimed
US-4687743-A Sunflower regeneration media, method of use and plants regenerated thereon STAUFFER CHEMICAL COMPANY (US) 1987-08-18 US claimed
EP-0222904-A1 METHOD FOR CLONAL PROPAGATION OF CONIFEROUS TREES BOARD OF CONTROL OF MICHIGAN TECHNOLOGICAL UNIVERSITY (US) 1987-05-27 EP claimed
US-4665031-A Clone of the sea kale (Crambe maritima L.), and process for vegetative propagation thereof Ecole Nationale d'Ingenieurs des Travaux (FR) 1987-05-12 US claimed
WO-1987001258-A1 HYDRATED, PREGERMINATED SEEDS IN GEL CAPSULES PLANT GENETICS, INC. (US) 1987-03-12 WO claimed
WO-1986007378-A1 METHOD FOR CLONAL PROPAGATION OF CONIFEROUS TREES BOARD OF CONTROL OF MICHIGAN TECHNOLOGICAL UNIVERS (US) 1986-12-18 WO claimed
EP-0192279-A1 Method of producing herbicide resistant plant varieties and plants produced thereby YEDA RESEARCH AND DEVELOPMENT LTD. (IL) 1986-08-27 EP claimed
US-4470840-A WITH SOLVENT, COMPOUNDS 2A,2B,3, AND 4, AND PLANT GROWTH REGULATOR BIOCHEMICAL RESEARCH CORPORATION (US) 1984-09-11 US claimed
US-4411685-A GROUP 2-5 METAL ION AND AUXIN IN SOLVENT BIOCHEMICAL RESEARCH CORPORATION (US) 1983-10-25 US claimed
US-4218473-A TREATMENT OF INFLAMMATORY SYNDROMES CENTRE EUROPEEN DE RECHERCHES MAUVERNAY (FR) 1980-08-19 US claimed
US-4110102-A AN AUXIN AND A GIBBERELLIN PHARIS RICHARD PERSONS 1978-08-29 US claimed