Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9276269 | 0.91 | ALK (0.43) | ALKLRRK2JAK2NTRK1TYK2 | |
| SCHEMBL2029409 | 0.87 | LRRK2 (0.45) | ALKLRRK2JAK2NTRK1TYK2 | |
| SCHEMBL2033545 | 0.84 | LRRK2 (0.50) | ALKLRRK2 | |
| SCHEMBL2029415 | 0.81 | LRRK2 (0.48) | ALKLRRK2JAK2NTRK1TYK2 | |
| SCHEMBL9276278 | 0.81 | ALK (0.43) | ALKLRRK2 | |
| SCHEMBL2637127 | 0.80 | PTK2 (0.66) | ALKLRRK2JAK2NTRK1TYK2 | |
| SCHEMBL2636973 | 0.80 | CDC7 (0.58) | ALKLRRK2JAK2NTRK1TYK2 | |
| SCHEMBL2637294 | 0.80 | LRRK2 (0.51) | ALKLRRK2 | |
| SCHEMBL2637381 | 0.79 | LRRK2 (0.57) | ALKLRRK2JAK2NTRK1TYK2 | |
| SCHEMBL2637475 | 0.79 | PTK2 (0.57) | ALKLRRK2JAK2NTRK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438056-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI Pharmaceuticals, LLC (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141406-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |