Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706158 | 0.86 | PDE10A (0.62) | PDE10A | |
| SCHEMBL2630829 | 0.84 | PDE10A (0.58) | PDE10A | |
| SCHEMBL7695813 | 0.83 | PDE10A (0.63) | PDE10A | |
| SCHEMBL7693747 | 0.83 | PDE10A (0.63) | PDE10A | |
| SCHEMBL2630963 | 0.83 | PDE10A (0.60) | PDE10A | |
| Hydrochloric Acid SCHEMBL2634059 | 0.82 | PDE10A (0.61) | PDE10A | |
| Hydrochloric Acid SCHEMBL15134916 | 0.82 | PDE10A (0.58) | PDE10A | |
| SCHEMBL2634175 | 0.82 | PDE10A (0.74) | PDE10A | |
| SCHEMBL7702977 | 0.81 | PDE10A (0.55) | PDE10A | |
| SCHEMBL7702975 | 0.81 | PDE10A (0.55) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569306-A1 | HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS | Amgen Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143366-A1 | HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |