Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | GJB2 | P29033 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MTAP | Q13126 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637305 | 1.00 | BCHE (0.46) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL13562761 | 0.87 | BCHE (0.49) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL13424410 | 0.87 | BCHE (0.49) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL21783270 | 0.87 | BCHE (0.49) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL14583809 | 0.87 | BCHE (0.49) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL2580825 | 0.87 | BCHE (0.49) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL2582793 | 0.87 | BCHE (0.49) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL12152898 | 0.87 | BCHE (0.49) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL14958003 | 0.83 | BCHE (0.46) | BCHEACHEPDE4DPDPK1MTOR | |
| SCHEMBL14697116 | 0.83 | BCHE (0.46) | BCHEACHEPDE4DPDPK1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726468-B1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC (CA) | 2017-04-12 | — | — | EP | disclosed |
| EP-2744338-B1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2016-04-27 | — | — | EP | disclosed |
| EP-2569291-B1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | UNIV FRASER SIMON (CA) | 2016-04-06 | — | — | EP | disclosed |
| US-9199949-B2 | Selective glycosidase inhibitors and uses thereof | ALECTOS THERAPEUTICS INC. (CA) | 2015-12-01 | — | — | US | disclosed |
| US-9126957-B2 | Selective glycosidase inhibitors and uses thereof | MERCK SHARP & DOHME CORP. (US) | 2015-09-08 | — | — | US | disclosed |
| US-9120781-B2 | Selective glycosidase inhibitors and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2015-09-01 | — | — | US | disclosed |
| US-20150045346-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-02-12 | — | — | US | disclosed |
| US-20140206665-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS INC. (CA) | 2014-07-24 | — | — | US | disclosed |
| US-20130131044-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | SIMON FRASER UNIVERSITY (CA) | 2013-05-23 | — | — | US | disclosed |
| EP-2569291-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | Simon Fraser University (CA) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011140640-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | SIMON FRASER UNIVERSITY (CA) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045346-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ENGASE, OGA, GALE | BCHE 590/4885ACHE 1142/4885PDE4D 1657/4885 |
| US-20140206665-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ENGASE, OGA, GALE | BCHE 563/4885ACHE 1366/4885PDE4D 1942/4885 |
| US-20130131044-A1 | SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF | ENGASE, OGA, GALE | BCHE 632/4885ACHE 1227/4885PDE4D 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.