Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 16/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637310 | 0.92 | FGFR1 (0.47) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL2032579 | 0.91 | PTK2 (0.52) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL2636967 | 0.91 | FGFR1 (0.45) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL2637244 | 0.90 | PTK2 (0.43) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL14767996 | 0.90 | PTK2 (0.45) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL9273872 | 0.90 | HDAC3 (0.44) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL2637116 | 0.89 | KDR (0.51) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL2637338 | 0.89 | PTK2 (0.42) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL2032585 | 0.89 | PTK2 (0.44) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL2636855 | 0.88 | FGFR1 (0.42) | PTK2JAK2NTRK1TYK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399433-B2 | Amino pyrimidine anticancer compounds | OSI Pharmaceuticals, LLC (US) | 2013-03-19 | — | — | US | disclosed |
| EP-2438056-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI Pharmaceuticals, LLC (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141406-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |