Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4164344 | 0.89 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1CREBBP | |
| SCHEMBL4164348 | 0.89 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1CREBBP | |
| SCHEMBL4164354 | 0.89 | MEN1 (0.46) | MEN1GAAKMT2AFOXO1CREBBP | |
| SCHEMBL261593 | 0.89 | KMT2A (0.49) | MEN1GAAKMT2AFOXO1CREBBP | |
| SCHEMBL265623 | 0.85 | KMT2A (0.53) | MEN1GAAKMT2AFOXO1CREBBP | |
| SCHEMBL263742 | 0.85 | MEN1 (0.45) | MEN1GAAKMT2AFOXO1POLB | |
| SCHEMBL261474 | 0.83 | KMT2A (0.49) | MEN1GAAKMT2AFOXO1CREBBP | |
| SCHEMBL4180734 | 0.80 | MEN1 (0.49) | MEN1GAAKMT2AFOXO1CREBBP | |
| Hydrochloric Acid SCHEMBL261650 | 0.80 | MEN1 (0.52) | MEN1GAAKMT2AFOXO1CREBBP | |
| SCHEMBL4165411 | 0.80 | MEN1 (0.52) | MEN1GAAKMT2AFOXO1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |