Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 6/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144712 | 0.75 | NOTUM (0.48) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL1586140 | 0.72 | NOTUM (0.38) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL262364 | 0.72 | NOTUM (0.39) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL30719692 | 0.71 | NOTUM (0.53) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL1197121 | 0.70 | NOTUM (0.43) | NOTUMALDH1A1MAPTLMNAHTT | |
| SCHEMBL1195851 | 0.69 | NOTUM (0.55) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL21467262 | 0.67 | NOTUM (0.56) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL4219987 | 0.67 | NOTUM (0.40) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL25252690 | 0.66 | MAPT (0.36) | NOTUMKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL20973018 | 0.66 | NOTUM (0.46) | NOTUMKDM4EALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134007-B2 | Pyridine derivatives | PFIZER INC. (US) | 2012-03-13 | — | — | US | disclosed |