SCHEMBL2637511

SCHEMBL2637511

CC(O)[C@@H](I)Nc1nc(NCc2cccc(O)c2O)c2ncn(C(C)C)c2n1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 10/20 0.63
CCNB1 P14635 7/20 0.63
CCNB2 O95067 4/20 0.63
CCNB3 Q8WWL7 4/20 0.63
CDK2 P24941 16/20 0.62
CCNE1 P24864 12/20 0.62
CDK5 Q00535 10/20 0.62
CDK9 P50750 8/20 0.62
CDK5R1 Q15078 6/20 0.62
CCNT1 O60563 5/20 0.62
CACNA1B Q00975 1/20 0.62
CDK7 P50613 8/20 0.56
CCNH P51946 6/20 0.56
CDK4 P11802 4/20 0.55
CCND1 P24385 3/20 0.55
MAPK1 P28482 3/20 0.55
CCNE2 O96020 1/20 0.54
CDK3 Q00526 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL786759 0.86 CDK2 (0.74) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL786760 0.86 CDK2 (0.74) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL15117670 0.80 CDK2 (0.73) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL15118052 0.79 CDK2 (0.73) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL15117893 0.78 CDK2 (0.79) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL786103 0.77 CDK2 (0.69) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL786102 0.77 CDK2 (0.69) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL15117672 0.77 CDK2 (0.61) CDK1CCNB1CCNB2CCNB3CDK2
SCHEMBL15117821 0.77 CDK2 (0.68) CDK1CCNB1CCNB2CCNB3CDK2
Olomoucine Ii SCHEMBL786673 0.77 CDK2 (1.00) CDK1CCNB1CCNB2CCNB3CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2438068-A1 SUBSTITUTED 6-(2-HYDROXYBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THESE DERIVATIVES Univerzita Palackého v Olomouci (CZ) 2012-04-11 EP disclosed
WO-2010139289-A1 SUBSTITUTED 6-(2-HYDROXYBENZYLAMINO)PURINE DERIVATIVES, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THESE DERIVATIVES UNIVERZITA PALACKEHO V OLOMOUCI (CZ) 2010-12-09 WO disclosed