Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22261364 | 0.86 | JAK3 (0.59) | AURKARPS6KB1AURKBJAK2JAK3 | |
| SCHEMBL1080984 | 0.84 | AURKA (0.52) | AURKARPS6KB1AURKBJAK2JAK3 | |
| SCHEMBL19831345 | 0.84 | PTK2 (0.47) | PTK2JAK2JAK3NTRK1TYK2 | |
| SCHEMBL690794 | 0.81 | CD38 (0.49) | AURKARPS6KB1AURKBCDC7ROCK2 | |
| SCHEMBL1202633 | 0.80 | CDC7 (0.70) | AURKBKDRCDC7ROCK2MAP4K4 | |
| SCHEMBL6193447 | 0.79 | PRKCQ (0.53) | AURKARPS6KB1AURKBMAP4K4PIM1 | |
| SCHEMBL22261128 | 0.78 | JAK3 (0.57) | AURKARPS6KB1JAK2JAK3TYK2 | |
| SCHEMBL22261044 | 0.77 | JAK3 (0.59) | AURKARPS6KB1AURKBJAK2JAK3 | |
| SCHEMBL22261230 | 0.77 | HDAC3 (0.52) | AURKARPS6KB1JAK2JAK3TYK2 | |
| SCHEMBL22261135 | 0.77 | JAK3 (0.49) | AURKARPS6KB1AURKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438056-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI Pharmaceuticals, LLC (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141406-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |