Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 5/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2036561 | 0.90 | ALK (0.47) | PTK2ALKLRRK2EGFRMAP4K1 | |
| SCHEMBL2636831 | 0.88 | PTK2 (0.54) | PTK2ALKLRRK2 | |
| SCHEMBL2637312 | 0.87 | PTK2 (0.62) | PTK2 | |
| SCHEMBL2637291 | 0.87 | PTK2 (0.49) | PTK2ALKLRRK2EGFR | |
| SCHEMBL2036562 | 0.86 | ALK (0.50) | PTK2ALKLRRK2 | |
| SCHEMBL15226876 | 0.84 | PTK2 (0.52) | PTK2ALKLRRK2 | |
| SCHEMBL2637073 | 0.83 | PTK2 (0.52) | PTK2ALKLRRK2 | |
| Trifluoroacetic Acid SCHEMBL2637077 | 0.83 | PTK2 (0.51) | PTK2ALKLRRK2 | |
| SCHEMBL2637127 | 0.83 | PTK2 (0.66) | PTK2ALKLRRK2EGFR | |
| Trifluoroacetic Acid SCHEMBL15226604 | 0.82 | PTK2 (0.54) | PTK2ALKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096624-B2 | Amino pyrimidine anticancer compounds | OSI Pharmaceuticals, LLC (US) | 2015-08-04 | — | — | US | disclosed |
| US-20130231306-A1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI Pharmaceuticals, LLC (US) | 2013-09-05 | — | — | US | disclosed |
| EP-2438056-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI Pharmaceuticals, LLC (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141406-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231306-A1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | DPYD, PTK2, TYMS | PTK2 2/4885ALK 872/4885LRRK2 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.