SCHEMBL2638458

SCHEMBL2638458

C/C(C(=O)O)=C(\C)C(=O)Nc1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAPRT Q6XQN6 1/20 0.59
HSD17B10 Q99714 1/20 0.59
SMN1; SMN2 Q16637 3/20 0.52
EPHX1 P07099 2/20 0.52
TP53 P04637 1/20 0.52
TSHR P16473 1/20 0.52
EPHX2 P34913 1/20 0.52
CDK9 P50750 1/20 0.52
CLK4 Q9HAZ1 1/20 0.52
NPC1 O15118 4/20 0.52
RAB9A P51151 4/20 0.52
MAPT P10636 3/20 0.52
TAAR1 Q96RJ0 2/20 0.52
KMT2A Q03164 1/20 0.52
POLB P06746 1/20 0.52
PTPN1 P18031 1/20 0.52
PTPN11 Q06124 1/20 0.52
CYP19A1 P11511 2/20 0.50
GPR35 Q9HC97 1/20 0.50
GAA P10253 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10420669 1.00 NAPRT (0.59) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL13324799 0.85 NAPRT (0.61) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL8526360 0.85 NAPRT (0.61) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL14379300 0.85 NAPRT (0.61) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL8511246 0.81 NAPRT (0.61) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL8511248 0.81 NAPRT (0.61) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL5170779 0.80 NAPRT (0.67) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL3415038 0.80 NAPRT (0.67) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL10863747 0.80 NAPRT (0.55) NAPRTHSD17B10SMN1; SMN2EPHX1TP53
SCHEMBL13648584 0.80 NAPRT (0.55) NAPRTHSD17B10SMN1; SMN2EPHX1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4748806-B2 2011-08-17 JP claimed
US-7211316-B2 Optical multilayer NITTO DENKO CORPORATION (JP) 2007-05-01 US claimed
WO-2005121848-A1 MULTILAYERED OPTICAL COMPENSATOR FILM WITH AMORPHOUS POLYMER FOR LIQUID CRYSTAL DISPLAYS NITTO DENKO CORPORATION (JP) 2005-12-22 WO claimed
WO-2005045820-A1 OPTICAL MULTILAYER EASTMAN KODAK COMPANY (US) 2005-05-19 WO claimed
US-20050089676-A1 Optical multilayer EASTMAN KODAK COMPANY 2005-04-28 US claimed
WO-2007001999-A1 MULTILAYERED OPTICAL COMPENSATOR NITTO DENKO CORPORATION (JP) 2007-01-04 WO disclosed