Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640095 | 1.00 | BRAF (0.46) | BRAFACVR1MAP3K14MAP3K12MAPK10 | |
| SCHEMBL13940917 | 0.89 | ACVR1 (0.44) | ACVR1MAP3K14 | |
| SCHEMBL2639448 | 0.87 | BRAF (0.51) | BRAFACVR1 | |
| SCHEMBL2639591 | 0.87 | BRAF (0.48) | BRAFACVR1MAP3K14 | |
| SCHEMBL2639900 | 0.86 | BRAF (0.50) | BRAFACVR1MAP3K14MAPK10CCNT1 | |
| SCHEMBL2639645 | 0.85 | BRAF (0.53) | BRAFMAPK10CCNT1CCNA2CDK2 | |
| SCHEMBL2640008 | 0.84 | BRAF (0.63) | BRAF | |
| SCHEMBL2956057 | 0.83 | BRAF (0.51) | BRAFACVR1MAP3K14MAPK10 | |
| SCHEMBL2639706 | 0.83 | BRAF (0.48) | BRAFACVR1MAP3K12CCNT1CCNA2 | |
| SCHEMBL2639978 | 0.82 | BRAF (0.47) | BRAFACVR1MAP3K14MAP3K12CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4792126-B2 | — | — | 2011-10-12 | — | — | JP | claimed |
| EP-2183243-A2 | PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS | Pfizer Inc. (US) | 2010-05-12 | — | — | EP | claimed |
| WO-2009016460-A2 | PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | claimed |
| EP-2183243-A2 | PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS | Pfizer Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009016460-A2 | PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS | PFIZER INC. (US) | 2009-02-05 | — | — | WO | disclosed |