Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 14/20 | 0.58 |
| ▸ | JAK3 | P52333 | 13/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640537 | 0.81 | JAK2 (0.59) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2635356 | 0.75 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2640587 | 0.73 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2640453 | 0.73 | JAK2 (0.72) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL3759808 | 0.71 | JAK2 (0.64) | JAK2PTK2JAK3 | |
| SCHEMBL3805633 | 0.71 | JAK2 (0.68) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2634434 | 0.71 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2640391 | 0.70 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2634731 | 0.69 | JAK2 (1.00) | JAK2PTK2JAK3JAK1 | |
| SCHEMBL2634780 | 0.67 | JAK2 (0.59) | JAK2PTK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438066-A2 | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES | Cephalon, Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141796-A2 | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES | CEPHALON, INC. (US) | 2010-12-09 | — | — | WO | disclosed |