Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264084 | 1.00 | MAPT (0.52) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL265171 | 0.95 | MAPT (0.53) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL296147 | 0.94 | MAPT (0.48) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL263725 | 0.90 | MAPT (0.54) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL263724 | 0.90 | MAPT (0.54) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL264143 | 0.89 | MAPT (0.56) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL263689 | 0.89 | MAPT (0.55) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL264273 | 0.87 | MAPT (0.53) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL263953 | 0.84 | MAPT (0.56) | MAPTTP53RXFP1ALDH1A1TSHR | |
| SCHEMBL263265 | 0.84 | MAPT (0.61) | MAPTTP53RXFP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133998-B2 | Bicyclic pyrimidine derivatives as calcium channel blockers | Zalicus Pharmaceuticals, Ltd. (CA) | 2012-03-13 | — | — | US | claimed |
| US-8133998-B2 | Bicyclic pyrimidine derivatives as calcium channel blockers | Zalicus Pharmaceuticals, Ltd. (CA) | 2012-03-13 | — | — | US | disclosed |