Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264118 | 0.87 | MEN1 (0.59) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL264528 | 0.86 | KMT2A (0.64) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL264569 | 0.84 | MAPT (0.70) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL268839 | 0.84 | MAPT (0.53) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL264772 | 0.84 | KMT2A (0.59) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL264773 | 0.84 | KMT2A (0.59) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL264083 | 0.83 | MEN1 (0.62) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL265278 | 0.82 | MEN1 (0.61) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL263886 | 0.82 | SMN1; SMN2 (0.61) | KMT2AMEN1MAPTTP53POLB | |
| SCHEMBL264808 | 0.81 | MEN1 (0.62) | KMT2AMEN1MAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133998-B2 | Bicyclic pyrimidine derivatives as calcium channel blockers | Zalicus Pharmaceuticals, Ltd. (CA) | 2012-03-13 | — | — | US | claimed |
| US-8133998-B2 | Bicyclic pyrimidine derivatives as calcium channel blockers | Zalicus Pharmaceuticals, Ltd. (CA) | 2012-03-13 | — | — | US | disclosed |