⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23529 | 0.76 | — | — | |
| SCHEMBL24677915 | 0.75 | — | — | |
| SCHEMBL15626931 | 0.75 | — | — | |
| Ammonia Solution, Strong SCHEMBL17457516 | 0.73 | — | — | |
| SCHEMBL18480151 | 0.70 | EPHX1 (0.35) | — | |
| SCHEMBL7807411 | 0.70 | — | — | |
| SCHEMBL5259026 | 0.70 | — | — | |
| SCHEMBL3044058 | 0.70 | — | — | |
| SCHEMBL12682254 | 0.70 | — | — | |
| SCHEMBL23528 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11732261-B2 | Selective antisense compounds and uses thereof | IONIS PHARMACEUTICALS, INC. (US) | 2023-08-22 | — | — | US | disclosed |
| US-20230056189-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF PATHOLOGIC PAIN ASSOCIATED WITH MALIGNANT GROWTH DISORDER | DUKE UNIVERSITY | 2023-02-23 | — | — | US | disclosed |
| US-20180028555-A1 | 2'-METHOXY SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS | IONIS PHARMACEUTICALS, INC. (US) | 2018-02-01 | — | — | US | disclosed |
| US-20180010126-A1 | ANTISENSE COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2018-01-11 | — | — | US | disclosed |
| US-20180010128-A1 | OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAs | Regulus Therapeutics Inc. (US) | 2018-01-11 | — | — | US | disclosed |
| US-20170369880-A1 | COMPOSITIONS COMPRISING ALTERNATING 2'-MODIFIED NUCLEOSIDES FOR USE IN GENE MODULATION | IONIS PHARMACEUTICALS, INC. (US) | 2017-12-28 | — | — | US | disclosed |
| US-9827263-B2 | 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations | IONIS PHARMACEUTICALS, INC. (US) | 2017-11-28 | — | — | US | disclosed |
| US-20170335322-A1 | COMPOUNDS AND METHODS FOR THE MODULATION OF COMP | IONIS PHARMACEUTICALS, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170327824-A1 | SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170283804-A1 | ANTISENSE COMPOUNDS AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2017-10-05 | — | — | US | disclosed |
| US-7875733-B2 | Nucleosides; RNA interference; gene expression inhibition; for use in therapeutic, diagnostic, and research applications involving gene silencing | ISIS PHARMACEUTICALS, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-20100324277-A1 | OLIGOMERIC COMPOUNDS COMPRISING 4'-THIONUCLEOSIDES FOR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | US | disclosed |
| US-7678895-B2 | Antisense modulation of superoxide dismutase 1, soluble expression | ISIS PHARMACEUTICALS, INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-20090298174-A1 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs | REGULUS THERAPEUTICS, LLC. (US) | 2009-12-03 | — | — | US | disclosed |
| US-20090291907-A1 | Oligomeric Compounds And Compositions For Use In Modulation Of Small Non-Coding RNAs | REGULUS THERAPEUTICS, LLC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090203896-A1 | MODULATION OF SURVIVIN EXPRESSION | ISIS PHARMACEUTICALS, INC. | 2009-08-13 | — | — | US | disclosed |
| US-7339051-B2 | Compositions and methods for the treatment of severe acute respiratory syndrome (SARS) | ISIS PHARMACEUTICALS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-20080027019-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN | ISIS PHARMACEUTICALS, INC. (US) | 2008-01-31 | — | — | US | disclosed |
| US-7220787-B2 | Photoreactive hot-melt adhesive composition | SEKISUI CHEMICAL CO., LTD. (JP) | 2007-05-22 | — | — | US | disclosed |
| US-20070054869-A1 | Antisense modulation of superoxide dismutase 1, soluble expression | BIOGEN MA INC. | 2007-03-08 | — | — | US | disclosed |