Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.67 |
| ▸ | IKZF2 | Q9UKS7 | 16/20 | 0.66 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23374633 | 1.00 | CRBN (0.67) | CRBNIKZF2IKZF1 | |
| SCHEMBL23423439 | 1.00 | CRBN (0.67) | CRBNIKZF2IKZF1 | |
| SCHEMBL20231313 | 0.91 | CRBN (0.67) | CRBNIKZF2IKZF1 | |
| SCHEMBL23877078 | 0.91 | IKZF2 (0.59) | CRBNIKZF2IKZF1 | |
| SCHEMBL30369165 | 0.90 | CRBN (0.61) | CRBNIKZF2IKZF1 | |
| SCHEMBL20765303 | 0.90 | CRBN (0.61) | CRBNIKZF2IKZF1 | |
| SCHEMBL20765304 | 0.90 | CRBN (0.61) | CRBNIKZF2IKZF1 | |
| SCHEMBL20765770 | 0.90 | CRBN (0.61) | CRBNIKZF2IKZF1 | |
| SCHEMBL30368979 | 0.90 | CRBN (0.61) | CRBNIKZF2IKZF1 | |
| SCHEMBL24319424 | 0.90 | CRBN (0.66) | CRBNIKZF2IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-B1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS INC (US) | 2023-09-27 | — | — | EP | disclosed |