Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21452961 | 0.81 | CHRM2 (0.41) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL6442167 | 0.81 | CHRM2 (0.53) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL433051 | 0.81 | CHRM2 (0.41) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL3744023 | 0.81 | CHRM2 (0.41) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL3744207 | 0.81 | CHRM2 (0.41) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL24364276 | 0.81 | MEN1 (0.42) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL18878053 | 0.81 | CHRM2 (0.53) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL3738809 | 0.81 | CHRM2 (0.53) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL3733652 | 0.79 | MEN1 (0.41) | CHRM2CHRM1CHRM3MEN1KMT2A | |
| SCHEMBL20187325 | 0.79 | CHRM2 (0.40) | CHRM2CHRM1CHRM3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544972-B1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | PFIZER (US) | 2023-04-26 | — | — | EP | disclosed |