Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2641645 | 1.00 | FGFR1 (0.42) | FGFR1PTK2KDRKITFLT3 | |
| SCHEMBL14767907 | 0.90 | FGFR1 (0.42) | FGFR1PTK2KDRKITFLT3 | |
| SCHEMBL14767909 | 0.90 | FGFR1 (0.42) | FGFR1PTK2KDRKITFLT3 | |
| SCHEMBL12974574 | 0.87 | PTK2 (0.50) | FGFR1PTK2KDRJAK2NTRK1 | |
| SCHEMBL2035830 | 0.87 | PTK2 (0.50) | FGFR1PTK2KDRJAK2NTRK1 | |
| SCHEMBL2035834 | 0.86 | PTK2 (0.43) | FGFR1PTK2KDRKITFLT3 | |
| SCHEMBL2636964 | 0.84 | FGFR1 (0.42) | FGFR1PTK2KDRJAK2NTRK1 | |
| SCHEMBL12586772 | 0.81 | PTK2 (0.51) | FGFR1PTK2KDRJAK2NTRK1 | |
| SCHEMBL2035153 | 0.80 | PTK2 (0.44) | FGFR1PTK2KDRJAK2NTRK1 | |
| SCHEMBL31260496 | 0.78 | KDR (0.53) | FGFR1PTK2KDRJAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438056-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI Pharmaceuticals, LLC (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141406-A2 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |