SCHEMBL26416639

SCHEMBL26416639

Nc1ccc(NC(=O)c2c(F)c(F)c(C(=O)Nc3ccc(N)c(C(F)(F)F)c3)c(F)c2F)cc1C(F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.54
HTT P42858 2/20 0.49
LMNA P02545 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
TSHR P16473 1/20 0.49
FFAR4 Q5NUL3 3/20 0.48
ALDH1A1 P00352 2/20 0.47
KLK7 P49862 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
BLM P54132 1/20 0.46
GAA P10253 1/20 0.46
GRM4 Q14833 1/20 0.46
MAPT P10636 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
XBP1 P17861 1/20 0.46
MAPK1 P28482 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26416455 0.92 HTT (0.55) ARHTTLMNASMN1; SMN2TSHR
SCHEMBL26416635 0.84 MAPT (0.62) ARHTTLMNAFFAR4MAPT
SCHEMBL2979818 0.81 AR (0.59) ARHTTLMNASMN1; SMN2FFAR4
SCHEMBL26416669 0.81 TSHR (0.54) HTTSMN1; SMN2TSHRALDH1A1KLK7
SCHEMBL14972641 0.81 PTGS1 (0.66) ARHTTLMNACA1CA2
SCHEMBL3531261 0.81 MAPT (0.70) ARHTTLMNAFFAR4MAPT
SCHEMBL6814369 0.80 MEN1 (0.60) HTTLMNASMN1; SMN2GRM4MAPT
SCHEMBL5460078 0.80 AR (0.62) ARFFAR4ALDH1A1L3MBTL1BLM
SCHEMBL28895734 0.79 MAPT (0.57) ARHTTLMNAMAPTNPSR1
SCHEMBL26416456 0.77 MAPT (0.62) ARHTTLMNASMN1; SMN2FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230125363-A1 Polyamideimide Precursor, Polyamideimide Prepared Therefrom, and Polyamideimide Film Including the Same SK IE TECHNOLOGY CO., LTD. (KR) 2023-04-27 US disclosed