Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 7/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28240637 | 0.86 | BTK (0.51) | BTKJAK1JAK2TYK2 | |
| SCHEMBL31226866 | 0.84 | IRAK4 (0.49) | IRAK4PARP1PARP2BTKPARP3 | |
| SCHEMBL27758269 | 0.74 | NOTUM (0.38) | IRAK4BTKJAK1JAK2TYK2 | |
| SCHEMBL3069502 | 0.74 | LRRK2 (0.35) | BTKJAK1JAK2TYK2 | |
| SCHEMBL28184239 | 0.74 | PARP1 (0.61) | IRAK4PARP1PARP2PARP3 | |
| SCHEMBL31561223 | 0.73 | BTK (0.43) | IRAK4BTKPAK1JAK1JAK2 | |
| SCHEMBL23178439 | 0.73 | TLR8 (0.44) | — | |
| SCHEMBL30158029 | 0.73 | PARP2 (0.51) | IRAK4PARP1PARP2PARP3 | |
| SCHEMBL28863344 | 0.72 | BTK (0.43) | BTKJAK1JAK2 | |
| SCHEMBL27758258 | 0.72 | BTK (0.40) | IRAK4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |