Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.64 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.51 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 8/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648342 | 0.85 | FGFR1 (0.59) | FGFR1HPGDNPC1RAB9AMEN1 | |
| SCHEMBL1762218 | 0.84 | FGFR1 (0.50) | FGFR1HPGDGABRA1GABRG2GABRB3 | |
| SCHEMBL2943514 | 0.83 | HPGD (0.58) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2337170 | 0.82 | FGFR1 (0.60) | FGFR1HPGDNPC1RAB9AKMT2A | |
| SCHEMBL2940112 | 0.82 | HPGD (0.60) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2944419 | 0.81 | HPGD (0.58) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL6752853 | 0.80 | HPGD (0.59) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2570944 | 0.78 | FGFR1 (1.00) | FGFR1HPGDKDRNPC1RAB9A | |
| SCHEMBL2648630 | 0.78 | FGFR1 (0.56) | FGFR1HPGDKDRNPC1RAB9A | |
| SCHEMBL30158779 | 0.78 | FGFR1 (0.55) | FGFR1PDCD1CD274HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563001-B1 | Imidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1996-02-28 | — | — | EP | disclosed |
| US-5360809-A | Imidazole compounds and their use as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-11-01 | — | — | US | disclosed |
| EP-0563001-A1 | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1993-09-29 | — | — | EP | disclosed |