Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK2 | Q9H0K1 | 16/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 3/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 9/20 | 0.38 |
| ▸ | SIK1 | P57059 | 8/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32691523 | 0.89 | SIK2 (0.44) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL21593330 | 0.87 | SIK2 (0.58) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL21593487 | 0.85 | SIK2 (0.48) | SIK2EZH2SIK3SIK1CYP2C9 | |
| SCHEMBL30131022 | 0.84 | SIK2 (0.50) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL21593303 | 0.82 | SIK2 (0.44) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL26439513 | 0.79 | SIK2 (0.41) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL21593383 | 0.78 | SIK2 (0.41) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL32691269 | 0.78 | SIK2 (0.41) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL26439618 | 0.78 | SIK2 (0.41) | SIK2SIK3SIK1CYP2C9CYP2C19 | |
| SCHEMBL21593288 | 0.75 | CYP1A2 (0.33) | SIK2EZH2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023066204-A1 | SIK INHIBITOR, COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海美悦生物科技发展有限公司 | 2023-04-27 | — | — | WO | disclosed |