Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.49 |
| ▸ | CBFB | Q13951 | 14/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GCK | P35557 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646299 | 0.87 | GCK (0.39) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 | |
| SCHEMBL2645178 | 0.85 | NPC1 (0.55) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 | |
| SCHEMBL2645879 | 0.75 | GCK (0.39) | NPC1CBFBHPGDCYP3A4CYP2C19 | |
| SCHEMBL2647458 | 0.71 | GCK (0.42) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 | |
| SCHEMBL2645683 | 0.71 | CBFB (0.43) | NPC1RAB9ARUNX1CBFBGCK | |
| SCHEMBL2647096 | 0.70 | GCK (0.44) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 | |
| SCHEMBL2645245 | 0.68 | CBFB (0.63) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 | |
| SCHEMBL10351275 | 0.67 | NPC1 (1.00) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 | |
| SCHEMBL2645214 | 0.67 | CBFB (0.54) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 | |
| SCHEMBL2644975 | 0.66 | CBFB (0.46) | NPC1RAB9ARUNX1CBFBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |