Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 12/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2644582 | 0.92 | CBFB (0.44) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2644460 | 0.92 | CBFB (0.44) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2646807 | 0.91 | GCK (0.36) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2644104 | 0.91 | CBFB (0.43) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2646321 | 0.91 | CBFB (0.43) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2646007 | 0.90 | CBFB (0.42) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2644519 | 0.87 | CBFB (0.45) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2645885 | 0.86 | GCK (0.40) | CBFBALDH1A1TP53CYP3A4CYP2D6 | |
| SCHEMBL2645339 | 0.86 | GCK (0.52) | CBFBGCK | |
| SCHEMBL2645048 | 0.86 | GCK (0.37) | CBFBCYP3A4CYP2C19GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |