Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.69 |
| ▸ | TP53 | P04637 | 5/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16071463 | 0.89 | MAPT (0.67) | MAPTTP53THRBIKBKBLIMK1 | |
| SCHEMBL19737752 | 0.84 | MAPT (0.85) | MAPTTP53THRBTDP1ROCK2 | |
| SCHEMBL15788385 | 0.81 | MAPT (0.62) | MAPTTP53THRBIKBKBLIMK1 | |
| SCHEMBL14955120 | 0.81 | MAPT (0.71) | MAPTTP53THRBIKBKBLIMK1 | |
| SCHEMBL19737751 | 0.80 | MAPT (0.72) | MAPTTP53THRBTDP1LIMK1 | |
| SCHEMBL19737573 | 0.79 | MAPT (0.88) | MAPTTP53THRBTDP1LIMK1 | |
| SCHEMBL14955252 | 0.79 | MAPT (0.78) | MAPTTP53THRBTDP1POLB | |
| SCHEMBL19737574 | 0.79 | MAPT (0.64) | MAPTTP53THRBTDP1ROCK2 | |
| SCHEMBL30598364 | 0.78 | TDP1 (0.65) | MAPTTP53TDP1IKBKBLIMK1 | |
| SCHEMBL14955291 | 0.78 | TDP1 (0.65) | MAPTTP53TDP1IKBKBLIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024112918-A1 | RNA DEGRADERS AND USES THEREOF | ARRAKIS THERAPEUTICS, INC. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2023077077-A1 | RNA DEGRADERS AND USES THEREOF | ARRAKIS THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |