Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.72 |
| ▸ | CDK2 | P24941 | 4/20 | 0.72 |
| ▸ | CCND1 | P24385 | 2/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.72 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.72 |
| ▸ | FECH | P22830 | 1/20 | 0.72 |
| ▸ | CCND3 | P30281 | 1/20 | 0.72 |
| ▸ | CDK9 | P50750 | 1/20 | 0.72 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.72 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.72 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.72 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.72 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.72 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.72 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.72 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.72 |
| ▸ | CDK1 | P06493 | 7/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16882814 | 0.99 | CDK4 (0.71) | CDK4CDK2CCND1GAKCCNT1 | |
| SCHEMBL31607902 | 0.90 | CDK4 (0.72) | CDK4CDK2CCND1GAKCCNT1 | |
| SCHEMBL1990676 | 0.89 | CDK1 (0.77) | CDK4CDK2CDK1 | |
| SCHEMBL30729675 | 0.89 | CDK1 (0.80) | CDK4CDK2CCND1GAKCCNT1 | |
| SCHEMBL31726934 | 0.89 | CDK1 (0.77) | CDK4CDK2CDK1 | |
| SCHEMBL1988670 | 0.89 | CDK1 (0.80) | CDK4CDK2CCND1GAKCCNT1 | |
| SCHEMBL30729677 | 0.89 | CDK1 (0.77) | CDK4CDK2CDK1 | |
| SCHEMBL2300882 | 0.88 | CDK1 (0.76) | CDK4CDK2CDK1 | |
| SCHEMBL1990635 | 0.88 | CDK1 (0.71) | CDK4CDK2CCND1GAKCCNT1 | |
| SCHEMBL31607838 | 0.88 | CDK1 (0.71) | CDK4CDK2CCND1GAKCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024086361-A1 | MOLECULAR GLUE DEGRADER COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2024-04-25 | — | — | WO | disclosed |
| WO-2023066350-A1 | CRBN E3 LIGASE LIGAND COMPOUND, PROTEIN DEGRADING AGENT DEVELOPED ON THE BASIS OF LIGAND COMPOUND, AND THEIR APPLICATIONS | 标新生物医药科技(上海)有限公司 | 2023-04-27 | — | — | WO | disclosed |