Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.39 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | GCK | P35557 | 3/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645874 | 1.00 | CNR2 (0.39) | CNR2CNR1GCKTAS1R3TAS1R1 | |
| SCHEMBL2645675 | 1.00 | CNR2 (0.39) | CNR2CNR1GCKTAS1R3TAS1R1 | |
| SCHEMBL2645681 | 1.00 | CNR2 (0.39) | CNR2CNR1GCKTAS1R3TAS1R1 | |
| SCHEMBL2645519 | 0.88 | CNR2 (0.38) | CNR2CNR1GCKTAS1R3TAS1R1 | |
| SCHEMBL2646406 | 0.88 | CNR2 (0.38) | CNR2CNR1GCKTAS1R3TAS1R1 | |
| SCHEMBL2646411 | 0.88 | CNR2 (0.38) | CNR2CNR1GCKTAS1R3TAS1R1 | |
| SCHEMBL2645515 | 0.88 | CNR2 (0.38) | CNR2CNR1GCKTAS1R3TAS1R1 | |
| SCHEMBL2645570 | 0.84 | GCK (0.40) | GCKEPHX2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL2645574 | 0.84 | GCK (0.40) | GCKEPHX2PIK3CDPIK3CAPIK3CG | |
| SCHEMBL2646058 | 0.84 | GCK (0.36) | CNR2CNR1GCKTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242397-B1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| EP-1242397-A1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6353111-B1 | WHICH INCREASE INSULIN SECRETION IN THE TREATMENT OF TYPE II DIABETES; 2,3-DI-SUBSTITUTED TRANS OLEFINIC N-HETEROAROMATIC OR URIDO PROPIONAMIDES: THE SUBSTITUTION AT THE 2-POSITION BEING A SUBSTITUTED PHENYL GROUP AND AT THE 3-POSITION A | HOFFMANN-LA ROCHE INC. | 2002-03-05 | — | — | US | disclosed |
| WO-2001044216-A1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-21 | — | — | WO | disclosed |