Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.50 |
| ▸ | CBFB | Q13951 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645526 | 0.94 | GCK (0.52) | GCKCBFBNPC1RAB9ARUNX1 | |
| SCHEMBL2645339 | 0.92 | GCK (0.52) | GCKCBFB | |
| SCHEMBL2646027 | 0.92 | GCK (0.49) | GCKCBFBNPC1RAB9ARUNX1 | |
| SCHEMBL2646481 | 0.90 | GCK (0.52) | GCKCBFBMETAP2METAP1 | |
| SCHEMBL2646292 | 0.90 | GCK (0.52) | GCKCBFBNPC1RAB9ARUNX1 | |
| SCHEMBL2646317 | 0.90 | GCK (0.53) | GCKCBFBNPC1RAB9ARUNX1 | |
| SCHEMBL2644729 | 0.87 | CBFB (0.48) | GCKCBFBNPC1RAB9ARUNX1 | |
| SCHEMBL2646320 | 0.87 | GCK (0.48) | GCKCBFBNPC1RAB9ARUNX1 | |
| SCHEMBL2646739 | 0.87 | GCK (0.48) | GCKCBFBNPC1RAB9ARUNX1 | |
| SCHEMBL2644460 | 0.86 | CBFB (0.44) | GCKCBFBNPC1RAB9ARUNX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |