Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.49 |
| ▸ | CBFB | Q13951 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2644782 | 0.86 | GCK (0.62) | GCK | |
| SCHEMBL2643943 | 0.84 | GCK (0.51) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2647193 | 0.83 | CBFB (0.41) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2644981 | 0.83 | GCK (0.53) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2645422 | 0.82 | GCK (0.53) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL3549191 | 0.81 | GCK (0.47) | GCK | |
| SCHEMBL2644037 | 0.79 | CBFB (0.49) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2645534 | 0.78 | GCK (0.50) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2645485 | 0.78 | CBFB (0.50) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2645829 | 0.78 | GCK (0.52) | GCKCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |