Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.45 |
| ▸ | ITGAV | P06756 | 3/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26464681 | 1.00 | POLB (0.53) | POLBROCK1PRKACACDK8GSK3A | |
| SCHEMBL26464679 | 1.00 | POLB (0.53) | POLBROCK1PRKACACDK8GSK3A | |
| SCHEMBL19323511 | 0.88 | POLB (0.56) | POLBROCK1PRKACAGSK3AGSK3B | |
| SCHEMBL14393699 | 0.88 | POLB (0.56) | POLBROCK1PRKACAGSK3AGSK3B | |
| SCHEMBL19324313 | 0.88 | POLB (0.56) | POLBROCK1PRKACAGSK3AGSK3B | |
| SCHEMBL14277951 | 0.85 | POLB (0.56) | POLBITGB3ITGAVITGA2BKCNA5 | |
| SCHEMBL26620685 | 0.85 | POLB (0.56) | POLBITGB3ITGAVITGA2BKCNA5 | |
| SCHEMBL7010730 | 0.84 | POLB (0.55) | POLBROCK1PRKACAGSK3AGSK3B | |
| SCHEMBL26464683 | 0.81 | ROCK1 (0.55) | ROCK1PRKACACDK8GSK3AGSK3B | |
| SCHEMBL26464682 | 0.81 | ROCK1 (0.55) | ROCK1PRKACACDK8GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023072974-A1 | TRICYCLIC HETEROCYCLES | MERCK PATENT GMBH (DE) | 2023-05-04 | — | — | WO | disclosed |