Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 7/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26466390 | 0.91 | CACNA1H (0.49) | CACNA1HCYP2D6KCNH2CACNA1GCACNA1I | |
| SCHEMBL26466387 | 0.91 | CACNA1H (0.49) | CACNA1HCYP2D6KCNH2CACNA1GCACNA1I | |
| SCHEMBL26466398 | 0.91 | CACNA1H (0.49) | CACNA1HCYP2D6KCNH2CACNA1GCACNA1I | |
| SCHEMBL26466247 | 0.85 | HPGD (0.50) | MEN1KMT2AALDH1A1 | |
| SCHEMBL26466419 | 0.85 | HPGD (0.50) | MEN1KMT2AALDH1A1 | |
| SCHEMBL26466238 | 0.85 | HPGD (0.50) | MEN1KMT2AALDH1A1 | |
| SCHEMBL26466609 | 0.84 | CACNA1H (0.52) | CACNA1HCYP2D6KCNH2CACNA1GCACNA1I | |
| SCHEMBL26498854 | 0.84 | CYP2D6 (0.54) | CACNA1HCYP2D6KCNH2CACNA1GCACNA1I | |
| SCHEMBL26466386 | 0.84 | CACNA1H (0.45) | CACNA1HMEN1KMT2AALDH1A1LTA4H | |
| SCHEMBL26466613 | 0.82 | CACNA1H (0.52) | CACNA1HCYP2D6KCNH2CACNA1GCACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |