Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26103898 | 0.86 | EGFR (0.71) | EGFRKCNH2IGF1R | |
| SCHEMBL29943943 | 0.86 | EGFR (0.71) | EGFRKCNH2IGF1R | |
| SCHEMBL17467210 | 0.85 | EGFR (1.00) | EGFRKCNH2IGF1R | |
| SCHEMBL17467212 | 0.83 | EGFR (0.71) | EGFRKCNH2IGF1R | |
| SCHEMBL19239596 | 0.83 | EGFR (0.87) | EGFRKCNH2 | |
| SCHEMBL26474195 | 0.82 | EGFR (0.65) | EGFRKCNH2 | |
| SCHEMBL19239594 | 0.82 | EGFR (0.82) | EGFRKCNH2 | |
| SCHEMBL17467209 | 0.82 | EGFR (1.00) | EGFRKCNH2IGF1R | |
| SCHEMBL17466926 | 0.82 | EGFR (1.00) | EGFRKCNH2 | |
| SCHEMBL17467207 | 0.81 | EGFR (1.00) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137932-A1 | CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2 | DANA-FARBER CANCER INSTITUTE, INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137932-A1 | CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2 | ERBB2, EGFR, ERBB3 | EGFR 2/4885KCNH2 4451/4885IGF1R 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.