Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 16/20 | 0.78 |
| ▸ | MAPK12 | P53778 | 16/20 | 0.78 |
| ▸ | MAPK11 | Q15759 | 16/20 | 0.78 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.78 |
| ▸ | RAF1 | P04049 | 8/20 | 0.78 |
| ▸ | GCGR | P47871 | 11/20 | 0.76 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469564 | 1.00 | MAPK13 (0.78) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6465619 | 0.93 | MAPK13 (0.90) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2647655 | 0.93 | MAPK14 (0.89) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2650776 | 0.92 | MAPK13 (0.74) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2648558 | 0.91 | MAPK14 (0.74) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2648525 | 0.89 | MAPK13 (0.73) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6468431 | 0.88 | MAPK13 (0.73) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL6469901 | 0.88 | MAPK14 (0.78) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2650500 | 0.88 | MAPK14 (0.79) | MAPK13MAPK12MAPK11MAPK14RAF1 | |
| SCHEMBL2647500 | 0.88 | GCGR (0.76) | MAPK13MAPK12MAPK11MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | claimed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |