Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655594 | 0.93 | GLRA3 (0.40) | NR1H2NR1H3RXRAGABRA1GABRB2 | |
| SCHEMBL18047574 | 0.79 | FFAR1 (0.45) | NR1H2NR1H3EGFRCYP2C9CYP2C19 | |
| SCHEMBL2648416 | 0.79 | CA12 (0.47) | NR1H2NR1H3GABRA1GABRB2 | |
| SCHEMBL27274620 | 0.73 | GRM6 (0.37) | NR1H2NR1H3RXRACYP2C9CYP2C19 | |
| SCHEMBL1174843 | 0.73 | ESR1 (0.46) | GABRA1EGFRSERPINE1CRHBPCRHR2 | |
| SCHEMBL2655601 | 0.71 | PTPN11 (0.46) | GABRA1GABRB2 | |
| SCHEMBL2221008 | 0.71 | GRM6 (0.36) | NR1H2NR1H3RXRACYP2C9CYP2C19 | |
| SCHEMBL13414067 | 0.71 | NR1H2 (0.55) | NR1H2NR1H3EGFRCYP2C9CYP2C19 | |
| SCHEMBL31617762 | 0.71 | NR1H2 (0.40) | NR1H2NR1H3RXRAEGFRCRHBP | |
| SCHEMBL27721570 | 0.70 | NR1H2 (0.45) | NR1H2NR1H3RXRAEGFRCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |
| EP-0934274-A1 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | Bayer Corporation (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004528-A2 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | BAYER CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |