Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 10/20 | 0.59 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648258 | 0.88 | GCGR (0.76) | GCGRHSP90AB1 | |
| SCHEMBL2647492 | 0.87 | GCGR (0.61) | GCGRHSP90AB1 | |
| SCHEMBL2647550 | 0.86 | GCGR (0.64) | GCGR | |
| SCHEMBL2647985 | 0.85 | GCGR (0.80) | GCGR | |
| SCHEMBL2649572 | 0.85 | GCGR (0.60) | GCGR | |
| SCHEMBL2649148 | 0.85 | GCGR (0.63) | GCGR | |
| SCHEMBL2648322 | 0.84 | GCGR (0.62) | GCGR | |
| SCHEMBL2649085 | 0.83 | GCGR (0.63) | GCGRESR1ESR2 | |
| SCHEMBL2648506 | 0.81 | GCGR (0.53) | GCGRHSP90AB1 | |
| SCHEMBL2649178 | 0.79 | GCGR (0.51) | GCGRESR1ESR2HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | claimed |
| CN-1239474-A | Substituted pyridines and biphenyls as antihypercholesterolemic, antihyperlipidemic and antihyperglycemic agents | BAYER AG (US) | 1999-12-22 | — | — | CN | claimed |
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |
| CN-1239474-A | Substituted pyridines and biphenyls as antihypercholesterolemic, antihyperlipidemic and antihyperglycemic agents | BAYER AG (US) | 1999-12-22 | — | — | CN | disclosed |