Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
| ▸ | ADH4 | P08319 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646341 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2645537 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2648288 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2648292 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2646345 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2646343 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2645539 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2645541 | 1.00 | NPSR1 (0.34) | NPSR1GRIK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2646427 | 0.98 | GRIK1 (0.32) | NPSR1GRIK1MEN1KMT2AGRIK2 | |
| SCHEMBL2646429 | 0.98 | GRIK1 (0.32) | NPSR1GRIK1MEN1KMT2AGRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242397-B1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2005-09-28 | — | — | EP | disclosed |
| EP-1242397-A1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6353111-B1 | WHICH INCREASE INSULIN SECRETION IN THE TREATMENT OF TYPE II DIABETES; 2,3-DI-SUBSTITUTED TRANS OLEFINIC N-HETEROAROMATIC OR URIDO PROPIONAMIDES: THE SUBSTITUTION AT THE 2-POSITION BEING A SUBSTITUTED PHENYL GROUP AND AT THE 3-POSITION A | HOFFMANN-LA ROCHE INC. | 2002-03-05 | — | — | US | disclosed |
| WO-2001044216-A1 | TRANS OLEFINIC GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-21 | — | — | WO | disclosed |