Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 0.80 |
| ▸ | BRD2 | P25440 | 19/20 | 0.80 |
| ▸ | BRD3 | Q15059 | 18/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.59 |
| ▸ | TAF1 | P21675 | 1/20 | 0.59 |
| ▸ | EP300 | Q09472 | 1/20 | 0.59 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.59 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.59 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.59 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.59 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.59 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20270832 | 0.95 | BRD4 (0.84) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20288504 | 0.92 | BRD4 (0.80) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL26487321 | 0.92 | BRD4 (0.74) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20288538 | 0.91 | BRD4 (0.85) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20288945 | 0.91 | BRD4 (0.79) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL23467397 | 0.91 | BRD4 (0.79) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20270265 | 0.91 | BRD4 (0.85) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20270648 | 0.91 | BRD4 (0.79) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL20288828 | 0.91 | BRD4 (0.79) | BRD4BRD2BRD3CYP3A4CYP2C9 | |
| SCHEMBL26487336 | 0.91 | BRD4 (0.68) | BRD4BRD2BRD3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787768-B2 | Tetrahydroquinoline-based bromodomain inhibitors | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2023-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787768-B2 | Tetrahydroquinoline-based bromodomain inhibitors | BRDT, BRD4, BRD3 | BRD4 2/4885BRD2 4/4885BRD3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.