Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 8/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650783 | 0.88 | GCK (0.51) | GCKMEN1KMT2ALMNATSHR | |
| SCHEMBL2650444 | 0.87 | GCK (0.50) | GCKKCNH2MEN1KMT2ALMNA | |
| SCHEMBL2650193 | 0.87 | GCK (0.50) | GCKMEN1KMT2ALMNATSHR | |
| SCHEMBL2649877 | 0.87 | GCK (0.50) | GCKMEN1KMT2ALMNATSHR | |
| SCHEMBL2648958 | 0.84 | GCK (0.48) | GCKMEN1KMT2ALMNATSHR | |
| SCHEMBL2645135 | 0.83 | GCK (0.61) | GCKKCNH2MEN1KMT2ALMNA | |
| SCHEMBL2645139 | 0.83 | GCK (0.61) | GCKKCNH2MEN1KMT2ALMNA | |
| SCHEMBL2645207 | 0.83 | GCK (0.61) | GCKKCNH2MEN1KMT2ALMNA | |
| SCHEMBL2645203 | 0.83 | GCK (0.61) | GCKKCNH2MEN1KMT2ALMNA | |
| SCHEMBL2650499 | 0.82 | GCK (0.35) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311504-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014312-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |