Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 14/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648113 | 0.97 | HPGD (0.49) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2647958 | 0.93 | FGFR1 (0.44) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2649485 | 0.90 | HPGD (0.50) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2652306 | 0.90 | FGFR1 (0.48) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2649718 | 0.90 | FGFR1 (0.47) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2649255 | 0.88 | FGFR1 (0.47) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2654922 | 0.87 | FGFR1 (0.49) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2652558 | 0.87 | FGFR1 (0.52) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2651479 | 0.87 | FGFR1 (0.51) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2652145 | 0.86 | FGFR1 (0.48) | HPGDFGFR1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002050057-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF GABA-ALPHA MEDIATED DISORDERS | NEUROSEARCH A/S (DK) | 2002-06-27 | — | — | WO | claimed |
| WO-2002050057-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES FOR THE TREATMENT OF GABA-ALPHA MEDIATED DISORDERS | NEUROSEARCH A/S (DK) | 2002-06-27 | — | — | WO | disclosed |