Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649336 | 0.87 | TP53 (0.45) | POLBSMN1; SMN2TDP1GAATP53 | |
| SCHEMBL1343945 | 0.86 | TP53 (0.50) | POLBSMN1; SMN2TDP1GAATP53 | |
| SCHEMBL6693487 | 0.83 | TP53 (0.47) | POLBSMN1; SMN2GAATP53LMNA | |
| SCHEMBL1341790 | 0.83 | TP53 (0.48) | SMN1; SMN2GAATP53LMNAMAPT | |
| SCHEMBL1342685 | 0.83 | TP53 (0.48) | SMN1; SMN2GAATP53HPGDLMNA | |
| SCHEMBL1497603 | 0.82 | GAA (0.48) | SMN1; SMN2GAATP53LMNAMAPT | |
| SCHEMBL6701475 | 0.82 | TP53 (0.46) | SMN1; SMN2GAATP53LMNAMAPT | |
| SCHEMBL2650328 | 0.81 | GAA (0.46) | SMN1; SMN2GAATP53LMNAMAPT | |
| SCHEMBL1340636 | 0.81 | TP53 (0.45) | SMN1; SMN2GAATP53LMNAMAPT | |
| SCHEMBL6701127 | 0.80 | TP53 (0.46) | SMN1; SMN2GAATP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |