Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 3/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.31 |
| ▸ | MEN1 | O00255 | 6/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ITK | Q08881 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649399 | 0.94 | MAPT (0.38) | MAPTRAB9ANPC1ALDH1A1GAA | |
| SCHEMBL1342854 | 0.89 | MAPT (0.32) | MAPTGAAKMT2AMEN1 | |
| SCHEMBL1343203 | 0.88 | MAPT (0.38) | MAPTRAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL2651685 | 0.85 | MAPT (0.38) | MAPTRAB9ANPC1ALDH1A1GAA | |
| SCHEMBL1341606 | 0.83 | MAPT (0.31) | MAPTGAAKMT2AMEN1 | |
| SCHEMBL2650681 | 0.82 | MAPT (0.41) | MAPTRAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL1342389 | 0.82 | MAPT (0.37) | MAPTRAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL1343099 | 0.81 | MAPT (0.30) | MAPT | |
| SCHEMBL1342126 | 0.81 | MAPT (0.36) | MAPTRAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL1340110 | 0.81 | MAPT (0.33) | MAPTGAAKMT2AMEN1ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |