Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 11/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649269 | 0.94 | GCGR (0.47) | GCGRDAO | |
| SCHEMBL2649254 | 0.92 | GCGR (0.43) | GCGRDAOHMGCR | |
| SCHEMBL2648244 | 0.91 | GCGR (0.41) | GCGRDAOGABRA1GABRG2GABRB3 | |
| SCHEMBL2648481 | 0.87 | GCGR (0.50) | GCGRDAOHMGCR | |
| SCHEMBL2648098 | 0.87 | GCGR (0.43) | GCGRDAO | |
| SCHEMBL2648753 | 0.85 | GCGR (0.64) | GCGR | |
| SCHEMBL2648555 | 0.85 | GCGR (0.48) | GCGR | |
| SCHEMBL2647585 | 0.83 | GCGR (0.38) | GCGRDAOGABRA1 | |
| SCHEMBL2648096 | 0.82 | GCGR (0.47) | GCGRDAO | |
| SCHEMBL2648230 | 0.82 | GCGR (0.44) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | claimed |
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |