Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.74 |
| ▸ | HPGD | P15428 | 13/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680877 | 0.86 | FGFR1 (0.76) | FGFR1HPGDALDH1A1 | |
| SCHEMBL13002361 | 0.86 | FGFR1 (0.76) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL7989417 | 0.85 | FGFR1 (1.00) | FGFR1HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2649378 | 0.85 | FGFR1 (0.78) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2188923 | 0.85 | FGFR1 (0.74) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2650058 | 0.81 | FGFR1 (0.76) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2652689 | 0.81 | FGFR1 (0.69) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2650200 | 0.80 | FGFR1 (0.66) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL2648966 | 0.80 | FGFR1 (0.66) | FGFR1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL5783610 | 0.80 | FGFR1 (0.66) | FGFR1HPGDNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821682-B1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA-A RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2000-07-19 | — | — | EP | disclosed |
| US-5922725-A | Benzimidazole compounds and their use as modulators of the GABAA receptor complex | NEUROSEARCH A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| EP-0821682-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033191-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |