Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.53 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6313153 | 0.96 | MCHR1 (0.50) | MCHR1SCN8ASLC6A4SLC6A3TSHR | |
| SCHEMBL16268473 | 0.85 | SCN8A (0.54) | MCHR1SCN8ASLC6A4SLC6A3TSHR | |
| SCHEMBL2650572 | 0.83 | SLC6A4 (0.46) | MCHR1SCN8ASLC6A4SLC6A3TSHR | |
| SCHEMBL3542034 | 0.82 | CACNA1B (0.49) | MCHR1SCN8AEPHX2 | |
| Hydrochloric Acid SCHEMBL8446857 | 0.81 | SCN8A (0.57) | SCN8ATSHREPHX2NR1H4ALDH1A1 | |
| SCHEMBL10889965 | 0.80 | MCHR1 (0.60) | MCHR1SLC6A4SLC6A3EPHX2L3MBTL1 | |
| SCHEMBL13992690 | 0.79 | KDM4E (0.45) | MCHR1EPHX2ALDH1A1SMN1; SMN2CHRM2 | |
| SCHEMBL3962793 | 0.79 | SCN8A (0.54) | SCN8ASLC6A4TSHREPHX2NR1H4 | |
| SCHEMBL8348550 | 0.79 | SCN8A (0.55) | SCN8ATSHREPHX2NR1H4ALDH1A1 | |
| SCHEMBL5765031 | 0.78 | S1PR2 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613942-B1 | Nonpeptide; 4-hydroxy benzoic acid hydrazides | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-0994848-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |
| WO-1999001423-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 1999-01-14 | — | — | WO | disclosed |