Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.37 |
| ▸ | MEN1 | O00255 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1342823 | 0.94 | MAPT (0.36) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL1341071 | 0.94 | MAPT (0.41) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL2649854 | 0.89 | MAPT (0.35) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL2650442 | 0.88 | MAPT (0.37) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL1342635 | 0.85 | MAPT (0.37) | MAPTKMT2AMEN1TP53RAB9A | |
| SCHEMBL1342824 | 0.85 | MAPT (0.35) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL1343364 | 0.85 | MAPT (0.42) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL1343436 | 0.85 | MAPT (0.42) | MAPTKMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL1341182 | 0.84 | MAPT (0.36) | MAPTKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL1341345 | 0.84 | RXFP1 (0.39) | MAPTKMT2AMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |