Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | SETD1B | Q9UPS6 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 6/20 | 0.34 |
| ▸ | FPR2 | P25090 | 6/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650193 | 0.85 | GCK (0.50) | SMN1; SMN2GCKNPC1RAB9A | |
| SCHEMBL2649877 | 0.85 | GCK (0.50) | SMN1; SMN2GCKNPC1RAB9A | |
| SCHEMBL2650783 | 0.84 | GCK (0.51) | SMN1; SMN2GCKNPC1RAB9A | |
| SCHEMBL2657462 | 0.80 | SETD1B (0.35) | SMN1; SMN2GCKSETD1BFPR3FPR2 | |
| SCHEMBL2657463 | 0.80 | SETD1B (0.35) | SMN1; SMN2GCKSETD1BFPR3FPR2 | |
| SCHEMBL2650318 | 0.79 | GCK (0.32) | GCK | |
| SCHEMBL2650469 | 0.79 | GCK (0.32) | GCK | |
| SCHEMBL2649681 | 0.79 | GCK (0.34) | SMN1; SMN2GCK | |
| SCHEMBL2650347 | 0.79 | GCK (0.34) | SMN1; SMN2GCK | |
| SCHEMBL2650025 | 0.78 | GCK (0.33) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311504-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | claimed |
| WO-2002014312-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | claimed |
| WO-2006043036-A2 | TREATMENT OF DIABETES | THE UNIVERSITY OF NEWCASTLE (GB) | 2006-04-27 | — | — | WO | disclosed |
| EP-1311504-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014312-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |